Lipid Nanoparticles (LNP)
1. siRNA LNP
2. mRNA LNP
3. CRISPR-Cas9 LNP
Liposome
1. SUV (Small Unilamellar Vesicles, 20 – 100 nm): Doxorubicin Liposome
2. LUV (Large Unilamellar Vesicles, > 100 nm): Amphotericin B liposome
3. OLV (Oligolamellar Vesicles, 0.1 – 1 um)
4. MLV (Multilamellar Large Vesicles, > 0.5 um)
5. MVV (Multivesicular Vesicles, > 1um): Bupivacaine Depofoam Liposome
Nanoparticles (20-200 nm)
1. Paclitaxel Albumin-bound Nanoparticles
2. Docetaxel Albumin-bound Nanoparticles
Nanocrystals (20-1000 nm)
1. Paliperidone Palmitate Nanocrystals
Microspheres / Microparticles
1. Microspheres loaded with small molecules (50-100 um): Risperidone Microspheres
2. Microspheres loaded with peptides (20-50 um)：Leuprolide Microspheres
3. Uniform monodispersed microspheres (20 – 200 um)
Nanoemulsion & Self-emulsifying System
1. Nanoemulsion (10-1000 nm) is kinetically stable and is used to enhance the solubility of BCS II and IV drugs to improve bioavailability
2. Microemulsion (10-8000 nm) is thermodynamically stable and is used to enhance the solubility of BSC II and IV drugs to improve bioavailability
Micelle
1. Micelles are self-assembling nanosized colloidal particles with a hydrophobic core and hydrophilic shell currently used for the solubilization of various poorly soluble pharmaceuticals.
2. Micelles normally have particle size within the 5–50 nm range.
3. The concentration at which the monomeric amphiphile forms micelles is called the critical micelle concentration (CMC).
Resinate
1. Resinate is a ion-exchange resin, in which drug molecules are loaded inside resin matrix
2. Drug can be released slowly through the coating on the surface
Oral Fast Dissolving Film (ODF)
1. ODF uses a dissolving film or oral drug strip to administer drugs via absorption in the mouth (buccally or sublingually).
2. ODF avoid first pass effect and offers fast drug on-set time.
3. No water is required for administration.
Transdermal and Topicals
1. A transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream.
2. Transdermal avoid first pass effect and offers long term pharmacological effect.
3. The therapeutical effect can be local (Topicals) or systemic.